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Multiparametric MRI for the optimization of disease management in patients with concurrent NAFLD-CHB

Due to the rising obesity epidemic, prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing. In parallel, incidence of concurrent chronic hepatitis B (CHB) and NAFLD has been increasingly observed in clinical practice. A liver biopsy is the current “gold standard” for diagnosis and monitoring of these diseases. However, not only is this an invasive procedure, biopsies may be inaccurate due to heterogeneity of the disease. The limited size of a liver biopsy specimen may not provide an accurate analysis of the entire liver. For patients suffering from both NAFLD and CHB, doctors are faced with the clinical dilemma in ascertaining the predominant disease driving deterioration of liver health. Differentiation of these two disease processes would enable personalization of treatment and better liver disease management.

Multiparametric magnetic resonance imaging (MP-MRI) has emerged as a potential tool for the assessment of liver disease. Its metrics have been proven to correlate with key features of liver disease - specifically fat accumulation, iron overload, inflammation and scarring. A team at the Singapore General Hospital, led by Dr George Goh Boon Bee is investigating the use of MP-MRI in the setting of concurrent NAFLD-CHB. There is evidence that MP-MRI can identify different patterns of disease processes for autoimmune liver diseases. This study aims to identify imaging signatures that would differentiate between the two disease processes in patients with concurrent NAFLD-CHB.

Principal Investigator: George Goh Boon Bee

Institution: Singapore General Hospital

NHIC Ref: NHIC-I2I-1909003



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