Recent successes in cancer immunotherapy achieved predominantly through the use of immune checkpoint inhibitors have led to durable responses and disease remission among select cancers. Immune checkpoint inhibitors work by…

Tp53 is the most mutated gene across all cancer types. p53 mutations not only lead to loss of p53’s tumor-suppressor properties, but also confer on it oncogenic characteristics. Mutant p53…

Bacterial control is a central part of acne treatment. Active ingredients like benzoyl peroxide and antibiotics are commonly used to reduce the bacterial population on our skin but faces with…

Extensive wounds secondary to burns, trauma or disease remain a challenging clinical problem. Cultured epithelial autografts (CEA) expanded from patient’s own skin keratinocytes is an important resurfacing treatment modality when…

Adoptive cellular immunotherapy has emerged as one of the most promising advances in the treatment of cancers. Nevertheless, autologous immune cells for in vitro manipulation and subsequent reinfusion is often…

Ocular vascular complications are major causes of visual impairment and blindness worldwide. Advances in understanding the molecular mechanism of neovascularization led to the identification of vascular endothelial growth factor (VEGF).…

Ocular inflammation is a ubiquitous problem after any intraocular surgery, including cataract surgery, glaucoma filtration surgery, corneal transplantation and vitreoretinal surgery. The current gold standard for treatment is topical steroids,…

Fungal keratitis, the second-most dominant cause of corneal blindness among Asian populations, accounts for 40-50% of all cases of culture proven infectious keratitis. Effective management of fungal infections is hampered…

Surgical resection is the first-line treatment of cancers that from solid tumor. Recurrence of cancer that often leads to high patient mortality is contributed by incomplete tumor margins. Project team…

Tumor heterogeneity is one of the major limiting factors to the efficacy of molecular targeted approaches including the CAR-T immunotherapy for reducing solid tumor. Recent effort to modify mesenchymal stem…

Infection of a wound injury site represents a major problem in wound management. Burn injury wounds is especially susceptible to infections by both resident and hospital-acquired antibiotic resistant pathogens, leading…

Hematopoietic stem cell transplant (HSCT) is able to treat a range of malignant and benign blood/bone marrow (BM) disorders e.g. leukaemia, lymphoma and thalassemia. It also remains as a last…

Dry eye disease (DED), a condition of tear insufficiency and ocular damage, afflicts ~300 million people worldwide, impairs quality of life and is an enormous socioeconomic burden (>USD$55 billion annually).…

Dengue is endemic in over 100 countries, with an estimated 390 million infections per year, of which approximately 100 million develop acute disease. Currently, there is no specific treatment available…

Depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease. Selective serotonin-reuptake inhibitors (SSRIs) are the first line pharmacotherapy in depression…

Ureteric strictures result from fibrosis in the wall of the ureter, resulting in narrowing of the utereric lumen which could in turn lead to significant morbidity and loss of a…

Fibrosis is an essential process that is a critical for wound healing. However, excessive and maladaptive fibrosis is common in many disease conditions and is an important disease mechanism. Diseases…

The Natural Killer/T-cell lymphoma (NKTCL) is a subtype of Non-Hodgkin’s lymphoma (NHL) which is more prevalent in Asian and Native American populations. Despite the use of multi-agent chemotherapy and involved-field…

Therapeutic Efficacy of a Neutrophil Elastase Inhibitor AZD9668 in Idiopathic Pulmonary Fibrosis Idiopathic pulmonary fibrosis (IPF) is a chronic, irreversible and ultimately fatal disease, characterised by scarring of the lung…

Natriuretic peptide analogues with vasodilatory or renal activities for personalized care of heart failure patients Heart failure (HF) is a common, costly, frequently fatal condition and the leading cause of…

Systemic Lupus Erythematosus (SLE) is an autoimmune condition which affects multiple organ systems, including skin, mouth, joints, kidneys, heart, lungs, intestine and blood. It is a relapsing-remitting disease with alternating…

According to the World Health Organization, lower respiratory tract infections are the leading cause of deaths in lower and middle income countries. As a major outcome of respiratory tract infections,…

Haptoglobin detection using an integrated surface enhanced Raman spectroscopy (SERS) for intraoperative diagnosis of ovarian cancer Ovarian cancer is the most lethal disease of the female reproductive tract. Two key…

Evaluation of safety and efficacy of subconjunctival injection of liposomal tacrolimus for allergic conjunctivitis Ocular allergic disease is an eye inflammation caused by an allergic reaction to substances, like pollen…