Seizure detection is a critical component of electroencephalography (EEG) interpretation. Non-convulsive seizures are especially common in the intensive care unit (ICU) setting, and timely seizure detection allows for early intervention…
Ocular vascular complications are major causes of visual impairment and blindness worldwide. Advances in understanding the molecular mechanism of neovascularization led to the identification of vascular endothelial growth factor (VEGF).…
Acute hydrocephalus, characterized by excessive cerebrospinal fluid (CSF) in the brain, is a common problem associated with stroke and head injury. Excessive CSF has to be constantly drained through an…
Ocular inflammation is a ubiquitous problem after any intraocular surgery, including cataract surgery, glaucoma filtration surgery, corneal transplantation and vitreoretinal surgery. The current gold standard for treatment is topical steroids,…
Fungal keratitis, the second-most dominant cause of corneal blindness among Asian populations, accounts for 40-50% of all cases of culture proven infectious keratitis. Effective management of fungal infections is hampered…
Glaucoma is estimated to affect over 100 million people in the world by year 2040, half of which will reside in Asia. In Singapore, the prevalence of glaucoma is reported…
More than half of patients affected by the most common blinding diseases in the world (glaucoma, diabetic retinopathy) are not detected in time. The reason is that at their initial…
Dry eye disease (DED), a condition of tear insufficiency and ocular damage, afflicts ~300 million people worldwide, impairs quality of life and is an enormous socioeconomic burden (>USD$55 billion annually).…
Depression is the leading cause of disability worldwide, and is a major contributor to the global burden of disease. Selective serotonin-reuptake inhibitors (SSRIs) are the first line pharmacotherapy in depression…
Glaucoma is an irreversible eye disease and a leading cause of blindness worldwide. A major risk factor is increased intraocular pressure (IOP). When first-line treatments fail, glaucoma filtration surgery (GFS)…
Diabetic retinopathy (DR) poses a large economic burden on the healthcare system with nearly 1 in 10 diabetes patients developing vision-threatening DR. Early detection, accurate evaluation and timely treatments are…
Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the leading causes of blindness in the elderly worldwide. Current treatments, while effective, are not ideal in terms of delivery nor…
Myopia is a global health burden, with projections predicting that one-third of the world’s population will have myopia by 2020. In Singapore alone, more than 50% of 9 year olds…
Diagnosis and management of neurological disorders relies on visual review of electroencephalogram (EEG) data by specialized physicians. As the duration of EEG recordings ranges from 30 minutes to several weeks,…
Evaluation of safety and efficacy of subconjunctival injection of liposomal tacrolimus for allergic conjunctivitis Ocular allergic disease is an eye inflammation caused by an allergic reaction to substances, like pollen…
Wireless Miniaturised GonioPEN for irido-corneal imaging Glaucoma is an irreversible condition where a build-up of pressure inside the eye causes damage to the optic nerve, leading to permanent vision loss.…
