Recent successes in cancer immunotherapy achieved predominantly through the use of immune checkpoint inhibitors have led to durable responses and disease remission among select cancers. Immune checkpoint inhibitors work by…
Tp53 is the most mutated gene across all cancer types. p53 mutations not only lead to loss of p53’s tumor-suppressor properties, but also confer on it oncogenic characteristics. Mutant p53…
Adoptive cellular immunotherapy has emerged as one of the most promising advances in the treatment of cancers. Nevertheless, autologous immune cells for in vitro manipulation and subsequent reinfusion is often…
Surgical resection is the first-line treatment of cancers that from solid tumor. Recurrence of cancer that often leads to high patient mortality is contributed by incomplete tumor margins. Project team…
Fibrosis is an essential process that is a critical for wound healing. However, excessive and maladaptive fibrosis is common in many disease conditions and is an important disease mechanism. Diseases…
The Natural Killer/T-cell lymphoma (NKTCL) is a subtype of Non-Hodgkin’s lymphoma (NHL) which is more prevalent in Asian and Native American populations. Despite the use of multi-agent chemotherapy and involved-field…
Chemotherapy-induced peripheral neuropathy (CIPN) is a disabling side effect of chemotherapy and occurs in up to 90% of patients. There is no specific treatment to prevent or reverse the severe…
