contact us


The Zika virus (ZIKV) is an emerging infectious agent with severe socio-economic impact due to its potential detrimental effects on congenital malformation. However, accurate ZIKV diagnosis is complicated due to its overlapping symptoms with dengue fever, another viral disease prevalent in Southeast Asia. Moreover, standard laboratory techniques such as PCR and ELISA are laborious, time-consuming, require expensive instrumentation, and cost-ineffective in large-scale screening of undifferentiated febrile illnesses suspected of Zika infection. This project aims to develop a large-scale manufactured rapid diagnostic test (RDT) kit for the fast and accurate detection of ZIKV in point-of-care (POC) settings. The RDT will be inexpensive, user-friendly, and the results can be read by the naked eye within 15 minutes without additional instrumentation. The RDT can achieve sensitive and specific detection of the ZIKV non-structural 1 (NS1) antigen and anti-ZIKV IgG/IgM, without cross-reaction with the dengue virus (DENV), and will be essential for effective disease management.

Project Deliverables

In this collaboration between the National Centre for Infectious Diseases (NCID) and NanoBio Lab (NBL), the team aims to deliver optimized, stable, and large-scale produced Zika RDTs that have been clinically verified/validated, and ready for adoption as lab-developed tests.

Principal Investigator: Prof. Leo Yee Sin

Institution: Tan Tock Seng Hospital / National Centre for Infectious Diseases

NHIC Ref: NHIC-I2D-1812214



See all MEDTECH projects >

Development of highly conductive microneedle array for painless dental anaesthesia

Pain management during dental procedures is a cornerstone for successful everyday practice. Curre...

Modular Endoprosthesis for Mandible Reconstruction

Mandible defects may result from trauma, inflammatory diseases or upon tumour resection. The gold...


Diagnosis and management of neurological disorders relies on visual review of electroencephalogra...

Natriuretic peptide analogues for heart failure patients

Natriuretic peptide analogues with vasodilatory or renal activities for personalized care of hear...

Novel inhibitors for Natural Killer/T-cell lymphoma (NKTCL)

The Natural Killer/T-cell lymphoma (NKTCL) is a subtype of Non-Hodgkin’s lymphoma (NHL) which is...

Biomarker for Rapid Diagnosis and Prediction of Severity of Acute Pneumonia

According to the World Health Organization, lower respiratory tract infections are the leading ca...


Clinical Partners

nhg logonuhs logosinghealth


Academic Partners

lkc medicalnus faculty of dentistrynus sphnus somduke nus


Supporting Partners

bms ipodxdipinmrcSCRIseriSMARTEnterpriseSGCatalystSingaporeBioDesign