contact us


The Zika virus (ZIKV) is an emerging infectious agent with severe socio-economic impact due to its potential detrimental effects on congenital malformation. However, accurate ZIKV diagnosis is complicated due to its overlapping symptoms with dengue fever, another viral disease prevalent in Southeast Asia. Moreover, standard laboratory techniques such as PCR and ELISA are laborious, time-consuming, require expensive instrumentation, and cost-ineffective in large-scale screening of undifferentiated febrile illnesses suspected of Zika infection. This project aims to develop a large-scale manufactured rapid diagnostic test (RDT) kit for the fast and accurate detection of ZIKV in point-of-care (POC) settings. The RDT will be inexpensive, user-friendly, and the results can be read by the naked eye within 15 minutes without additional instrumentation. The RDT can achieve sensitive and specific detection of the ZIKV non-structural 1 (NS1) antigen and anti-ZIKV IgG/IgM, without cross-reaction with the dengue virus (DENV), and will be essential for effective disease management.

Project Deliverables

In this collaboration between the National Centre for Infectious Diseases (NCID) and NanoBio Lab (NBL), the team aims to deliver optimized, stable, and large-scale produced Zika RDTs that have been clinically verified/validated, and ready for adoption as lab-developed tests.

Principal Investigator: Prof. Leo Yee Sin

Institution: Tan Tock Seng Hospital / National Centre for Infectious Diseases

NHIC Ref: NHIC-I2D-1812214



See all MEDTECH projects >


Diagnosis and management of neurological disorders relies on visual review of electroencephalogra...

A Rapid Point-of-Care Test Kit for Diagnosing Zika Virus Infection

The Zika virus (ZIKV) is an emerging infectious agent with severe socio-economic impact due to it...

A Force Sensor to Deliver Optimal Cricoid Pressure for Airway Protection

Cricoid pressure refers to the finger pressure applied over the cricoid cartilage on the neck dur...

Assay for Early Detection of Flares in Patients with Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is an autoimmune condition which affects multiple organ system...

Towards a Novel Drug Therapy for Treatment-Resistant Depression: Adjunct 5-HTP Slow-Release

Depression is the leading cause of disability worldwide, and is a major contributor to the global...

Swellable Drug Loaded Stent Coating for Ureteral Stricture

Ureteric strictures result from fibrosis in the wall of the ureter, resulting in narrowing of the...


Clinical Partners

nhg logonuhs logosinghealth


Academic Partners

lkc medicalnus faculty of dentistrynus sphnus somduke nus


Supporting Partners

bms ipodxdipinmrcSCRIseriSMARTEnterpriseSGCatalystSingaporeBioDesign