The technology is a method of determining the risk of cardiovascular disease (CVD) in patients with Type 2 Diabetes Mellitus (T2DM) as indicated by endothelial dysfunction. This is measured by analysing the waveform of the radial artery, presented as the magnetic flux disturbance the blood produces as it passes through an external magnetic field. Measurements will be done before and after compression (vessel occlusion), and an algorithm calculates the maximum distensibility index – a quantitative score that could potentially be correlated with cardiovascular risk.
In collaboration with engineering co-investigators the team will further develop the existing prototype device which is able to measure radial artery distensibility after a period of occlusion in a cost effective, operator independent and non-invasive manner. The team will then validate this device on healthy volunteers with two operators to establish satisfactory repeatability and reproducibility, inter and intra operator reliability and to establish satisfactory limits of agreement. Clinical validation will then be performed to compare with traditional risk factors and other methods of cardiovascular risk assessments.
Principal Investigator: Dr Rinkoo DALAN
Institution: Tan Tock Seng Hospital, National Healthcare Group
NHIC Ref: NHIC-I2D-1409002