contact us


Ureteric strictures result from fibrosis in the wall of the ureter, resulting in narrowing of the utereric lumen which could in turn lead to significant morbidity and loss of a functioning kidney. Treatment (and prevention) involves placing a ureteric stent within the ureter for up to 6 weeks, which is then removed.

Current stents serve only as passive internal scaffolds and do not address any pathology e.g. fibrosis, infection, tumours. The team has developed a novel swellable hydrogel coating which can be applied to commercially available stents, which allows drug elution of mitomycin C (MMC) to prevent fibrosis.

Project Deliverables

A MMC-loaded stent coating which has been tested for the following: i) safety and feasibility of insertion/removal of the stent in a pig model, ii) quantification of the drug concentration of MMC delivered by the coated stent in ureteric tissue, and iii) efficacy of MMC in preventing stricture formation.

Principal Investigator: Dr CHONG Tsung Wen

Institution: Singapore General Hospital

NHIC Ref: NHIC-I2D-1506051



See all BIOPHARMA projects >

Evaluation of an Improved Design of Vaginal Swab for Biological Sample Collection

Secretions from the cervix and vagina are routinely collected for laboratory testing. The current...

Mobile Interactive Supervised Therapy

Medication adherence in tuberculosis treatment is critical for patient’s cure, infection control...

A Rapid Point-of-Care Test Kit for Diagnosing Zika Virus Infection

The Zika virus (ZIKV) is an emerging infectious agent with severe socio-economic impact due to it...

Assay for Early Detection of Flares in Patients with Systemic Lupus Erythematosus

Systemic Lupus Erythematosus (SLE) is an autoimmune condition which affects multiple organ system...

Towards a Novel Drug Therapy for Treatment-Resistant Depression: Adjunct 5-HTP Slow-Release

Depression is the leading cause of disability worldwide, and is a major contributor to the global...

Novel inhibitors for Natural Killer/T-cell lymphoma (NKTCL)

The Natural Killer/T-cell lymphoma (NKTCL) is a subtype of Non-Hodgkin’s lymphoma (NHL) which is...


Clinical Partners

nhg logonuhs logosinghealth


Academic Partners

lkc medicalnus faculty of dentistrynus sphnus somduke nus


Supporting Partners

bms ipodxdipinmrcSCRIseriSMARTEnterpriseSG