contact us


Systemic Lupus Erythematosus (SLE) is an autoimmune condition which affects multiple organ systems, including skin, mouth, joints, kidneys, heart, lungs, intestine and blood. It is a relapsing-remitting disease with alternating disease-free and active periods; the active periods are known as flares, where active inflammation of organs and tissues takes place. Flares start subclinically (i.e. with increasing inflammation) and if untreated progress to clinical flares which manifest variously as rash, joint pains, low blood counts, seizures or blood/protein in the urine. All SLE patients are regularly monitored for development of flares as untreated clinical flares will result in organ damage and lead to irreversible damage, such as end stage kidney disease requiring lifelong dialysis.

In the current standard of care, there is an unmet medical need to detect patients with subclinical flares as existing markers of flares do not perform adequately.

Project Deliverables

A nanoparticle-based assay to detect subclinical flares in patients with SLE using tear samples, followed by validation in an SLE patient cohort.

Principal Investigator: Professor Julian Thumboo

Institution: Singapore General Hospital

NHIC Ref: NHIC-I2D-1604102



See all BIOPHARMA projects >

An In-office Trachealesophageal Puncture, Prosthesis Sizing and Insertion Device

Total laryngectomy involves the removal of a patient’s voice box and results in the loss of voici...

Evaluation of an Improved Design of Vaginal Swab for Biological Sample Collection

Secretions from the cervix and vagina are routinely collected for laboratory testing. The current...

SERID™ — A Diagnostic-Therapeutic Device for the Eye

Age-related macular degeneration (AMD) and diabetic retinopathy (DR) are the leading causes of bl...

Biomarker for Rapid Diagnosis and Prediction of Severity of Acute Pneumonia

According to the World Health Organization, lower respiratory tract infections are the leading ca...

Towards a Novel Drug Therapy for Treatment-Resistant Depression: Adjunct 5-HTP Slow-Release

Depression is the leading cause of disability worldwide, and is a major contributor to the global...

Natriuretic peptide analogues for heart failure patients

Natriuretic peptide analogues with vasodilatory or renal activities for personalized care of hear...


Clinical Partners

nhg logonuhs logosinghealth


Academic Partners

lkc medicalnus faculty of dentistrynus sphnus somduke nus


Supporting Partners

bms ipodxdipinmrcSCRIseriSMARTEnterpriseSGCatalystSingaporeBioDesign